Eflornithine m salt InChiKey: YMYJXFUPMPMETB-UHFFFAOYSA-N

InChiKey: YMYJXFUPMPMETB-UHFFFAOYSA-N

InChi: InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10

5-dioxo-N-[2-[2-[3-oxo-3-[[4-[3-oxo-3-(2-oxo-1-azetidinyl)propyl]phenyl]amino]propoxy]ethoxy]ethyl]-1H-pyrrole-1-propanamide

is a potent and selective DDR1 inhibitor with IC50 of 105 nM

Epub 2011 Jun 25

Eflornithine m salt InChiKey: YMYJXFUPMPMETB-UHFFFAOYSA-NEflornithine, also known as Difluoromethylornithine, is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of