S1RA Size:Solid 2 mg regulators of the β-catenin destruction

regulators of the β-catenin destruction complex

Smiles: OC(=O)C=C(CCC1C=CC(Cl)=CC=1)C1C=CC=CC=1

InChiKey: ZFLWDHHVRRZMEI-CYBMUJFWSA-N

ML-329 shows specific activity against the MITF-dependent cells

Smiles: OC(=O)C1C=C(O)C=C(C=1)NC(=O)NC1=CC2=CC=CC=C2C=C1

S1RA Size:Solid 2 mg regulators of the β-catenin destructionE 52862, also known as S1RA and MR390, is a selective sigma 1 receptor antagonist, with a reported binding affinity of Ki = 17. 0 7. 0 nM, selective over the sigma 2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state. E