RJR-2403 - CAS# 15585-43-0 26481585 Small Molecule Inhibition of the

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

also known as AM630

The cumulative change in food intake and weight gain increases dose-dependently

1530/REP-12-0099

939983-14-9 (rel)

RJR-2403 - CAS# 15585-43-0 26481585 Small Molecule Inhibition of theMetanicotine, also known as RJR 2403 and TC 2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the 42 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 + 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 + 155 nM and Emax = 91 + 8% for RJR 2403; EC50 = 591 + 120 nM and Emax = 100 + 25% for nicotine) . Chronic administration of RJR 2403 in combination with low