Tuberin(Phospho Thr1462) Polyclonal Antibody, 50ul Plasma Gene Ontology (GO) annotations related

Gene Ontology (GO) annotations related to this gene include death receptor binding

An important paralog of this gene is GK

inducing leukocyte migration and activation

The PIAS family contains a conserved RING domain that has been linked to a function as a small ubiquitin-related modifier (SUMO) ligase

The encoded protein binds to single-stranded DNA coated with replication protein A

Tuberin(Phospho Thr1462) Polyclonal Antibody, 50ul Plasma Gene Ontology (GO) annotations relatedMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.