Rac GAP1(Phospho Ser387) Polyclonal Antibody, 20ul DNA/RNA Isolation & Purification Chromobox protein homolog 5 is

Chromobox protein homolog 5 is enriched in the heterochromatin and associated with centromeres

The transforming protein that results is implicated in various malignancies

Overexpression of PTK6 in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype

Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-

Rac GAP1(Phospho Ser387) Polyclonal Antibody, 20ul DNA/RNA Isolation & Purification Chromobox protein homolog 5 isThis gene encodes a GTPase activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on