NFKappaB-p105 Polyclonal Antibody, 50ul[BT-AP05980] Thermal Control Certain mutations in this gene

Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia

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It has been suggested to be involved in several basic biological events such as cell death

It has been shown to transport several compounds| including serotonin| dopamine| and the neurotoxin 1-methyl-4-phenylpyridinium

and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events

NFKappaB-p105 Polyclonal Antibody, 50ul[BT-AP05980] Thermal Control Certain mutations in this geneNFKB1 encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF kappa B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra and extra cellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and