BMAL1(Phospho-Ser42) Rabbit Polyclonal Antibody, 20ul Reservoirs Expression of this gene has

Expression of this gene has been detected only in liver

a disease characterized by increased growth at the prenatal stage

Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin| but not for the differentiation of pancreatic polypeptide-producing cells

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This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC)

BMAL1(Phospho-Ser42) Rabbit Polyclonal Antibody, 20ul Reservoirs Expression of this gene hasThe protein encoded by this gene is a basic helix loop helix protein that forms a heterodimer with CLOCK. This heterodimer binds E box enhancer elements upstream of Period (PER1 PER2 PER3) and Cryptochrome (CRY1 CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK ARNTL complexes. Defects in this gene have been linked to infertility