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CD59 Polyclonal Antibody, 50ul[BT-AP01935] Gene Synthesis Mutations in this gene may

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CD59 Polyclonal Antibody, 50ul[BT-AP01935] Gene Synthesis Mutations in this gene mayThe inter alpha trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

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Description

Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients

This gene encodes an EFNA class ephrin

This protein can be secreted through non-classical pathways and functions as an extracellular mitogen

Its substrates include antidepressants

and mediates activation of the RET tyrosine kinase receptor

CD59 Polyclonal Antibody, 50ul[BT-AP01935] Gene Synthesis Mutations in this gene mayThe inter alpha trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

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