GATA-1(Phospho Ser310) Polyclonal Antibody, 20ul Custom Peptide Synthesis DERL2 is involved in the

DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al

Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene

Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase| this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis

Mutations in this gene are associated with complement component-6 deficiency

the encoded protein may regulate differentiation

GATA-1(Phospho Ser310) Polyclonal Antibody, 20ul Custom Peptide Synthesis DERL2 is involved in theThis gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X linked dyserythropoietic anemia and thrombocytopenia.