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PKI Beta Polyclonal Antibody, 50ul Site-directed Mutagenesis Experiments with knockout mice indicate

SKU: 54377218910

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PKI Beta Polyclonal Antibody, 50ul Site-directed Mutagenesis Experiments with knockout mice indicatePKIB (protein kinase (cAMP dependent, catalytic) inhibitor beta) encodes a member of the cAMP dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of PKIB may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for PKIB.

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Description

Experiments with knockout mice indicate that this gene attenuates

and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors

RRN3 (RRN3 Homolog

Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death

Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis

PKI Beta Polyclonal Antibody, 50ul Site-directed Mutagenesis Experiments with knockout mice indicatePKIB (protein kinase (cAMP dependent, catalytic) inhibitor beta) encodes a member of the cAMP dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of PKIB may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for PKIB.

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