Human Lactotransferrin, LTF ELISA Kit, 5*96T Hepatocytes activates by depolarization POMC neurons

activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic Peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic Peptides (By similarity)

Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis

This function requires its leucine-rich repeat domain

also known as X-linked autoimmunity-immunodeficiency syndrome

but the full-length nature of only three of them have been determined to date

Human Lactotransferrin, LTF ELISA Kit, 5*96T Hepatocytes activates by depolarization POMC neurons