Tak1 Polyclonal Antibody, 20ul[BT-AP08812] Metabolic enzymes May play a specific role

May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity)

in normal adult tissues

Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types

An important paralog of this gene is TBC1D10C

and alterations in the expression of PAX5 are thought to contribute to neoplastic transformation

Tak1 Polyclonal Antibody, 20ul[BT-AP08812] Metabolic enzymes May play a specific roleThe protein encoded by MAP3K7 (mitogen activated protein kinase kinase kinase 7) is a member of the serine threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL 1, this protein forms a kinase complex including TRAF6, MAP3K7P1 TAB1 and MAP3K7P2 TAB2; this complex is