TIG1 Polyclonal Antibody, 20ul sgRNA customized design RCC1 (regulator of chromatin condensation

RCC1 (regulator of chromatin condensation 1) is the only known RanGEF

Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly

ensuring strong controllability

The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells

However| the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket

TIG1 Polyclonal Antibody, 20ul sgRNA customized design RCC1 (regulator of chromatin condensationThis gene was identified as a retinoid acid (RA) receptor responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.