UBE3B Polyclonal Antibody, 100ul ssDNA Synthesis A similar protein in yeast

A similar protein in yeast functions as a methylesterase| converting methylated diphthine to diphthine| which can then undergo amidation to produce diphthamide

mostly in proliferative tissues

Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis

including the neurotransmitters dopamine

Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease

UBE3B Polyclonal Antibody, 100ul ssDNA Synthesis A similar protein in yeastThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: e1 ubiquitin activating enzymes, E2 ubiquitin conjugating enzymes, and E3 ubiquitin protein ligases. UBE3B (ubiquitin protein ligase E3B) encodes a member of the E3 ubiquitin conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin