Rat Interleukin 18, IL-18 ELISA Kit, 96T Digital Burette PubMed: 19960512)

PubMed: 19960512)

The encoded protein was originally described in bile ducts of liver as biliary glycoprotein

It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner

May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity)

Regulates remodeling of the extracellular matrix by up-regulation of the Matrix Metalloproteinases MMP2

Rat Interleukin 18, IL-18 ELISA Kit, 96T Digital Burette PubMed: 19960512)A proinflammatory cytokine primarily involved in polarized T helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF kappa B, triggering synthesis of inflammatory mediators. Synergizes with IL12 interleukin 12 to induce IFNG synthesis from T helper 1 (Th1) cells and natural killer (NK) cells.