UBS3B Polyclonal Antibody, 20ul Sampling Tubes Endoplasmic reticulum aminopeptidase 1 encoded

Endoplasmic reticulum aminopeptidase 1 encoded by ERAP1 is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules

Alternative splicing of this gene results in transcript variants encoding different isoforms

and at a much lower levels in adipose tissue and in aorta

The encoded isozyme is a soluble cytoplasmic protein

Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds

UBS3B Polyclonal Antibody, 20ul Sampling Tubes Endoplasmic reticulum aminopeptidase 1 encodedThis gene encodes a protein that contains a ubiquitin associated domain at the N terminus, an SH3 domain, and a C terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet derived growth factor receptor.