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Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 50ul Apoptosis & Autophagy Another member of the CHP

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Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 50ul Apoptosis & Autophagy Another member of the CHPThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) bladder cancer and osteogenic sarcoma.

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Description

Another member of the CHP subfamily

thymus and fetal liver

It is a C-type lectin with mannose binding specificity

and possesses ubiquitin ligase E3 activity

Widely expressed in fetal tissues

Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 50ul Apoptosis & Autophagy Another member of the CHPThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) bladder cancer and osteogenic sarcoma.

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