AP4E1 Rabbit Polyclonal Antibody, 50ul Cryopreservation The protein localizes to the

The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation

This channel consists of two subunits

RICTOR and MAPKAP1

This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation

Five alternatively spliced transcript variants encoding distinct isoforms have been reported

AP4E1 Rabbit Polyclonal Antibody, 50ul Cryopreservation The protein localizes to theThis gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex 4, which is associated with both clathrin and nonclathrin coated vesicles. Disruption