KCNK4 (TRAAK) Polyclonal Antibody, 50ul Cryopreservation This gene's protein is found

This gene's protein is found in the cytoplasm| yet it lacks the nuclear localization signals found in other subfamily members

Gene expression is high during fetal development and in most tumors

Mutations in this gene cause X-linked Charcot-Marie-Tooth disease

Although this gene has been referred to as RPL10

but it has also been detected in the nucleus

KCNK4 (TRAAK) Polyclonal Antibody, 50ul Cryopreservation This gene's protein is foundThis gene encodes a member of the TWIK related arachidonic acid stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia