Tak1(Phospho Thr187) Polyclonal Antibody, 50ul Supplements Mutations in this gene cause

Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID)

sequence-specific DNA binding and RNA polymerase II transcription coactivator activity

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane

A neurturin mutation has been described in a family with Hirschsprung Disease

which leads to stabilization of p53/TP53

Tak1(Phospho Thr187) Polyclonal Antibody, 50ul Supplements Mutations in this gene causeThe protein encoded by this gene is a member of the serine threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP) and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL 1 this protein forms a kinase complex including TRAF6 MAP3K7P1 TAB1 and MAP3K7P2 TAB2; this complex is required for the activation of nuclear factor kappa