p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Pseudogenes of this gene are

Pseudogenes of this gene are present on chromosomes 1| 3| 9| 12 and 20| and on the X chromosome

The WW domains are essential for localization to nuclear speckles

This gene encodes a preproprotein that is proteolytically processed to generate two protein products| megakaryocyte potentiating factor and mesothelin

In addition| protein levels decrease in the presence of natural killer lytic-associated molecule| suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein

Calcium-dependent

p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Pseudogenes of this gene areThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.