ARMCX3 Polyclonal Antibody, 50ul Diagnostic Probes & Oligos Disruption of the TGF-beta/SMAD pathway

Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers

Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding

The PGBD proteins appear to be novel

and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals

The heavy chain is approximately 45 kDa and its gene contains 8 exons

ARMCX3 Polyclonal Antibody, 50ul Diagnostic Probes & Oligos Disruption of the TGF-beta/SMAD pathwayARMCX3 (armadillo repeat containing, X linked 3) encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. ARMCX3 is closely localized with other family members on the X chromosome. Three